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Cell counting development
The origin of cell counting and development
The hemocytometer (or haemocytometer) is counting-chamber device originally designed and usually used for counting blood cells. [1]
The hemocytometer was invented by Lousi-Charles Malassez and consists of a thick glass microscope slide with a rectangular indentation that creates a chamber. This chamber is engraved with a laser-etched grid of perpendicular lines. The device is carefully crafted so that the area bounded by the lines and the depth of the chamber are known. By observing a defined area of the grid. It is therefore possible to count the number of cells or particles in a specific volume of fluid, and thereby calculate the concentration of cells in the fluid overall. A common type of hemocytometer is the Neubauer counting chamber. [2]
How NanoEntek has developed to make cell counting simple and easy
To reduce inconvenience of hemocytomer, C-chip has been invented by NanoEntek. C-chip has no need to wash because it is disposable. C-chip does not require coverslips. It reduces time and effort but have a high accuracy
After releasing C-chip, NanoEntek started to develop automated cell counter which is CountessTM. NanoEntek supplied CountessTM to the company ' Life Technologies 社' exclusively. NanoEntek also released faster and more accurate automated cell counters 'EVE' and 'EVE PLUS'.
As the cell counters are made, it became possible to count the cells and check viability with automated image analysis.
The data can be seen as a graph which makes more convenient for users.
NanoEntek has released various products for purpose of cell counting. C-chip (2ch / 4ch) is a disposable hemocytometer that reduces time and effort but has a high accuracy. EVE Plus is one of the fastest cell counters that counts cells in one minute. ADAM-MC2 is an accurate cell counter by using PI staining. ADAM-CellT complies with 21 CFR part 11 which is available in cGMP production environment.
